How does it work?
ERR receptors are nuclear receptors that regulate the transcription of genes for mitochondrial capacity and aerobic metabolism. SLU-PP-332 was developed to activate the ERR system pharmacologically and thereby trigger parts of the gene response associated with physical exercise. The documentation is mainly animal and cell research.
Technical mechanism
Synthetic pan-agonist for oestrogen-related receptors (ERRα/β/γ). Used as a chemical probe in research on mitochondrial metabolism and exercise-like signalling.
What is being researched?
- ERRα/β/γ activation and aerobic exercise response
- Mitochondrial metabolism and oxidative capacity
- Preclinical models of metabolic syndrome and obesity
- Analytical characterisation and doping-relevant monitoring
About the evidence: SLU-PP-332 has preclinical data, but no established human clinical documentation. It should be presented as a research probe, not as a health or performance product.
Research profile
Studies and sources
The links go to independent research databases (PubMed, PubMed Central, ClinicalTrials.gov). The studies are in English and open in a new tab.
ERR activation and exercise response
The key studies show that SLU-PP-332 activates ERR signalling and exercise-like transcriptional programmes in preclinical models.
- Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity PreclinicalPubMed· 2023
This study described the development of SLU-PP-332 as an ERR agonist and showed an exercise-like gene response and increased endurance capacity in preclinical models. This is not human documentation.
- A Synthetic ERR Agonist Alleviates Metabolic Syndrome PreclinicalPubMed· 2024
This preclinical study investigated SLU-PP-332 in metabolic syndrome models and reported improvements in several metabolic measures. The study is relevant to mechanism and disease models, not clinical use.
Chemical optimisation and analysis
Recent studies investigate the structure, chemical optimisation and analytical detection of SLU-PP-332.
- Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling PreclinicalPubMed· 2026
This study investigated structural and optimisation work on SLU-PP-332 to better understand ERR signalling. It is useful for chemical probe context and mechanism.
- In Vitro Metabolism and Analytical Characterization of SLU-PP-332 and SLU-PP-915: Novel Pan-ERR Agonists With Doping Potential PreclinicalPubMed· 2026
This analytical study describes the in vitro metabolism and characterisation of SLU-PP-332 and SLU-PP-915, partly because the substances may be relevant to doping monitoring.