MOTS-C
Mitochondrially encoded peptide of 16 amino acids, used in research on metabolic regulation.
- 1–2 pcs€40 each
- 3+ pcs€36 each−10%
- 10+ pcs€32 each−20%
- Certificate of analysis for every batch
- Over 99% verified purity
- Ships from Norway
- Free shipping over NOK 2,500
Description and specifications
Description
MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA rather than the nuclear genome. In research models, the molecule is studied for its role in insulin sensitivity, AMPK signalling and metabolic homeostasis under physical exertion. Supplied as a lyophilised powder for reconstitution in the laboratory. For research use only (in vitro / laboratory use). Not for consumption, diagnostic or therapeutic use.
Research summary
MOTS-c is a small peptide of 16 amino acids that the body makes itself – it is encoded in a section of the mitochondria's own DNA (the so-called 12S rRNA region). Mitochondria are the "power stations" inside cells, and researchers have become interested in MOTS-c because its levels appear to be linked to how the body handles energy and blood sugar. By far most of the research so far has been done in cells and animals, and only a few studies have been carried out in humans.
Level of evidence: Almost all knowledge about MOTS-c comes from experiments in cells and animals (especially mice and rats). Human data are so far few and early – most are small observational studies that measure the body's natural MOTS-c levels, not large treatment studies. None of this is an approved treatment, and the content here is intended as research information only (Research Use Only).
This information is written for a laboratory and research context. The product is not intended for consumption, diagnostics or therapeutic use.
Specifications
| CAS | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Purity | ≥ 99 % (HPLC) |
| Size | 10 mg |
Batch information
Batch number, purity and document status are shown here for each published batch.
Need the certificate of analysis?
Contact ArcticAmino to receive a copy of the certificate of analysis (COA) for the product or batch.
Peptide guide
Research Use Only. Not for human consumption. Not medical advice. Always check information against primary sources and internal laboratory procedures.
Read the full guide (12 studies)MOTS-c, mitochondrial peptide (12S rRNA ORF-c)
Studies have investigated how MOTS-c appears to affect a central "energy sensor" system in cells called AMPK. When AMPK is activated, cells shift towards using sugar and fat as fuel. In experiments, MOTS-c has been linked to increased glucose uptake in muscle, including via the transporter GLUT4. Another property researchers have explored is that under stress the peptide can move into the cell nucleus and influence which genes are switched on and off. This is largely based on cell and animal models.
What is being researched?
- Insulin sensitivity and how the body regulates blood sugar (animal and cell studies)
- Activation of AMPK – the cells' energy sensor – and general energy metabolism
- Muscle function, physical capacity and age-related decline (animal studies)
- Body weight, fat tissue and high-fat-diet-induced obesity in animal models
- Cardiovascular function (animal models and observational data in humans)
Selected sources
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Why researchers choose ArcticAmino
- Certificate of analysis for every batch
- Over 99% verified purity
- Ships from Norway
- Next-day delivery
- Discreet packaging
- Norwegian customer service
- Free shipping over NOK 2,500
- For research purposes only
Often ordered together for lab set-ups.
